Assays / Protein Reference Units / Acetylcholine Receptor Antibody

Clinical use: The diagnosis and monitoring of Myasthenia gravis.

Raised levels of antibody are seen in 88% of patients with active Myasthenia gravis, 58% of patients in remission, and in 68% of patients with the restricted Ocular myasthenia. Although not univerally related to disease activity, antibody levels may be used to assess the effectiveness of plasma exchange therapy.

Sample requirement: 2 mL serum.

Reference range: Results are expressed in terms of a -bungarotoxin bound by the autoantibody, values up to 2 nmol/L are considered as normal.

Centres offering this assay: St George's, Sheffield

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