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Assays / Trace
Metals/ Nickel
Nickel is thought to be an essential trace element and plasma
concentrations are normally maintained within narrow limits. The
kidney is the main site of accumulation with smaller amounts in
the lung and adrenal. Nickel crosses the placenta into fetal tissue
and cord blood.
Nickel forms compounds with a range of oxidation states
and a variety of co-ordination complexes. The main uses are in the
formation of stainless steels and other corrosion resistant alloys,
and for electroplating, to produce a hard tarnish resistant surface.
Nickel and nickel compounds are widely used in coinage, enamel frits,
ceramic glazes, as catalysts in the hydrogenation of fats and oils
and as paint pigments. Substantial amounts are used in the manufacture
of rechargeable batteries and electronic components.
Deficiency
Deficiency states have been demonstrated experimentally
in animals, but have not been described in man.
Toxicity
Toxicity can result from occupational exposure
to certain compounds of the element. Acute toxicity can follow exposure
to nickel carbonyl, a gas generated as part of the refining process
for the metal. Headache, giddiness, nausea and vomiting may occur,
followed in severe cases by dyspnoea, weakness, mental confusion
and convulsions. Occupational exposure to nickel and its compounds
can cause an allergic dermatitis which can be severe. Dermatitis
due to the wearing of nickel plated objects such as jewellery is
well documented. Rarely, the nickel content of stainless steel orthopaedic
implants may cause an allergic dermatitis. Exposure to nickel-containing
dust can also result in sensitisation, causing conjunctivitis, pneumonitis
and asthma. An increased incidence of lung and nasal sinus cancer
occurs in those exposed long-term to some kinds of nickel ores.
Laboratory Indices of Exposure
Plasma or urine levels correlate with airborne
concentrations, but there is much greater increase in urinary excretion.
Measurement in urine is therefore preferred for monitoring exposure.
References:
Stokinger HE Chapter 29 - Metals, in Patty's
Industrial Hygiene and Toxicology, 3rd Revised Edition, Volume 2A.
Eds Clayton GD and Clayton FE. Wiley Interscience, 1981.
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