|
(Download our Thyroid Function Request form)
This laboratory is a joint NHS/ Academic Department of Clinical
Biochemistry at Addenbrooke's Hospital, where it provides
a full Clinical Biochemistry service to the hospital, and
is part of the Cambridge University Clinical School. The NHS
Department of Clinical Biochemistry at Addenbrooke's has held
full CPA accreditation since 1993 and provides three services
for the SAS:
1) Referred thyroid function tests. The department provides
a comprehensive suite of biochemical and genetic tests for
the investigation of unusual thyroid function tests including
thyroid hormone resistance, familial dysalbuminaemic hyperthyroximaemia,
'macro-TSH', anti-thyroid antibodies and thyroid binding inhibitory
immunoglobulin. New results are reviewed at a weekly MDT meeting
so appropriate clinical advice can be provided. Please contact
the lab for further information (djh44@hermes.cam.ac.uk) and
use the request card provided.
2) Severe insulin resistance. We provide an integrated clinical,
biochemical, immunological and genetic service for patients
with severe IR and support the NSCT Severe Insulin Resistance
Service
http://www.specialisedservices.nhs.uk/service/insulin-resistant-diabetes-service/
We have expertise in identifying and characterising both
genetic and acquired, immunologically-mediated forms of severe
IR and LD, and have developed diagnostic algorithms incorporating
biochemical triage and genetic testing. We are able to provide
advice on both diagnosis and management, and written patient
information literature. Clinical discussion prior to targeted
testing is strongly recommended to ensure the highest diagnostic
yield (insulin.resistance@addenbrookes.nhs.uk).
3) Investigation of macrohormones - we offer gel filtration
analysis where appropriate for the investigation of hormone:immunoglobulin
complexes, particularly macroprolactin and macro-TSH.
The SAS laboratory complements the research activities of
the two directors:
• Prof Chatterjee (Referred Thyroid Function Tests)
http://www.mrl.ims.cam.ac.uk/staff/PI/Chatterjee/
- Genetic and Molecular Endocrinology, with particular emphasis
on the role of nuclear hormone receptors in human disease.
• Prof O’Rahilly (Severe Insulin Resistance)
http://www.mrl.ims.cam.ac.uk/staff/hod/
- Mechanisms of Human Insulin Resistance and Molecular and
Pathophysiological Mechanisms in Obesity
Director – Thyroid Service: Professor VK Chatterjee
Director – Severe Insulin Resistance: Professor S O’Rahilly
|
