Norfolk & Norwich University Hospitals Calcium and Bone Metabolism Service

Norfolk and Norwich University Hospitals (NNUH) NHS Foundation Trust

The Calcium and Bone Metabolism Laboratory that was previously located the Royal Liverpool University Hospital site for over 30 years, moved to Norfolk and Norwich University Hospital in 2011. Both clinical and academic aspects of the management and investigation of bone metabolism were developed under the direction of Professor Bill Fraser. An international reputation has been established in the development, evaluation and application of assays for calcitropic hormones (PTH, PTHrP, vitamin D), bone/collagen metabolism (pyridinoline cross-links (PYD, DPD) telopeptides (CTX, NTX), pro-collagen molecules (P1NP, PIIINP), osteocalcin, TRAP5b and bone specific alkaline phosphatase) and intact and C-terminal fibroblast growth factor 23 (FGF23). The majority of these assays are available with either 1-2 weekly, or 3-4 weekly, turnaround times.

Other assays are available in a research capacity e.g. vitamin D binding protein, sclerostin, osteoprotegerin, and alpha klotho. Investigation protocols, consultation and advice are available for all aspects of bone and calcium metabolism, as part of the SAS.

Director: Professor Bill Fraser
Deputy Director: Dr Allison Chipchase

Tel: +44 (0)1603 287945

Norfolk and Norwich University Hospitals NHS Foundation Trust

Calcium and Bone Metabolism Laboratory
Laboratory Medicine
Level 1, East Block
Colney Lane

PLEASE NOTE: Our PTHrP service is currently suspended due to poor performance of the radioimmunoassay we use. We are currently developing an LC-MS method for PTHrP quantitation.